ANTI-INFLAMMATORY EFFECT OF BETA-BETA WOOD ETHANOLIC EXTRACT (LUNASIA AMARA BLANCO.) IN MICE MODEL OF RHEUMATOID ARTHRITIS

Hasnaeni, Hasnaeni ANTI-INFLAMMATORY EFFECT OF BETA-BETA WOOD ETHANOLIC EXTRACT (LUNASIA AMARA BLANCO.) IN MICE MODEL OF RHEUMATOID ARTHRITIS. International Journal of Toxicological and Pharmacological Research, 2 (3). pp. 353-359. ISSN 0975-5160

	Text (URL FILE JURNAL) IJTPR,Vol8,Issue5,Article8.pdf - Published Version Download (861kB)
	Text (Peer-Review) peerreview5.pdf Download (476kB)
	Text (SIMILARITY) 5. Similarity IJTPR.pdf Download (2MB)

Official URL: http://ijtpr.com/volume8issue5/

Abstract

Rheumatoid Arthritis (RA) causes damage to the joints that are affected by chronic inflammatory diseases. The aim of present study the anti-inflammatory effect of ethanolic extract Beta-beta wood (Lunasia amara Blanco.) in Complete Freund’s Adjuvant (FCA)-induced arthritis in mice. The ethanolic extract of L. amara (ELA) was orally administered once daily for 60 days after sub-plantar hind paw administration with CFA. The ability of the plant extract to reduce swelling as a sign of arthritic inflammation was assessed of volume of hind paw swelling. Tumor necrosis alpha (TNF-α), interleukin 6 (IL-6) and paw histopathology were also determined. The administration of ELA (50; 100, and 250 mg/kg BW) significant reduced volume of edema in mice-treated CFA (P<0.05) and the activity were equal to diclofenac sodium, 2 mg/kg BW. The reduction of edema were last until day 60. The administration of ELA was also significantly decreased the level of serum TNF-α and IL-6 in arthritis model in mice (P<0.05), but still less than diclofenac sodium. Histopathological examination indicated that ELA decrease edema and infiltration of inflammatory cells and synovial hyperplasia as well as protected joint destruction without osteoclast. The result suggests that ethanolic extract of L. amara might be beneficial for the treatment of chronic inflammatory disorder like rheumatoid arthritis

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	FAKULTAS FARMASI
Depositing User:	Unnamed user with email admin@umi.ac.id
Date Deposited:	16 Feb 2021 02:05
Last Modified:	04 Mar 2021 02:17
URI:	http://repository.umi.ac.id/id/eprint/214

Actions (login required)

View Item