Synthesis and evaluation of radiogalliumlabeled long-chain fatty acid derivatives as myocardial metabolic imaging agents

Effendi, Nurmaya (2021) Synthesis and evaluation of radiogalliumlabeled long-chain fatty acid derivatives as myocardial metabolic imaging agents. Plos One, 27 (2). pp. 383-393. ISSN 0968-0896

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Abstract

Since long-chain fatty acids work as the primary energy source for the myocardium, radiolabeled long-chain fatty acids play an important role as imaging agents to diagnose metabolic heart dysfunction and heart diseases. With the aim of developing radiogallium-labeled fatty acids, herein four fatty acid-based tracers, [ 67Ga]Ga-HBED-CC-PDA, [ 67Ga]Ga-HBED-CCMHDA, [ 67Ga]Ga-DOTA-PDA, and [ 67Ga]Ga-DOTA-MHDA, which are [ 67Ga]Ga-HBED-CC and [ 67Ga]Ga-DOTA conjugated with pentadecanoic acid (PDA) and 3-methylhexadecanoic acid (MHDA), were synthesized, and their potential for myocardial metabolic imaging was evaluated. Those tracers were found to be chemically stable in 0.1 M phosphate buffered saline. Initial [ 67Ga]Ga-HBED-CC-PDA, [ 67Ga]Ga-HBED-CC-MHDA, [ 67Ga]Ga-DOTAPDA, and [ 67Ga]Ga-DOTA-MHDA uptakes in the heart at 0.5 min postinjection were 5.01 ± 0.30%ID/g, 5.74 ± 1.02%ID/g, 5.67 ± 0.22%ID/g, and 5.29 ± 0.10%ID/g, respectively. These values were significantly lower than that of [ 123I]BMIPP (21.36 ± 2.73%ID/g). For their clinical application as myocardial metabolic imaging agents, further structural modifications are required to increase their uptake in the heart.

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	FAKULTAS FARMASI
Depositing User:	Unnamed user with email admin@umi.ac.id
Date Deposited:	26 May 2023 05:37
Last Modified:	26 May 2023 05:37
URI:	http://repository.umi.ac.id/id/eprint/2545

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