Standardization and bacteria inhibitory test of puriৎied extract of mahogany (swietenia mahagoni (L.) Jacq) seeds and leaves

Handayani, Virsa (2019) Standardization and bacteria inhibitory test of puriৎied extract of mahogany (swietenia mahagoni (L.) Jacq) seeds and leaves. International Journal of Research in Pharmaceutical Sciences, 10 (3). pp. 1550-1553. ISSN 0975-7538

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Official URL: https://ijrps.com/index.php/home/article/view/4024

Abstract

Mahogany (Swietenia mahagoni (L.) Jacq) is one of the plants that is often used by the community as traditional medicine. One of them is antifungal, antibacterial, antidiabetic, and eczema. This study aims to obtain standardized extracts from mahogany seeds and leaves. Standardization of puriϑied extract of mahogany has been carried out according to the monographs of extract standardization guidelines, which include testing of speciϑic and non-speciϑic parameters. The results of the speciϑic parameter testing showed that the puriϑied extract of mahogany seeds is a thick extract, brown to reddish, smells distinctive and has a bitter taste. While the puriϑied extract of mahogany leaves is a thick extract, greenish-brown in color, distinctive smell and has a bitter taste. The chemical content of puriϑied extract of mahogany seeds and leaves showed the presence of ϑlavonoids, alkaloids, terpenoids and saponins. Watersoluble essence levels in mahogany seeds and leaves was 14.84% and 10.28%. While the ethanol-soluble essence levels in mahogany seeds and leaves were 15.38% and 12.43%. Testing of non-speciϑic parameters on mahogany seeds and leaves showed the results of drying shrinkage levels of 0.22% and 8.84%, moisture content of 2.60% and 4.04%, total ash content of 1.71% and 1.93%, levels acidic insoluble ash 0.38% and 0.32%, Total Plate Number (ALT) of mahogany seed bacteria 1x102 colonies/g, Number of mahogany mold seeds 4x10 colonies/g, heavy metal lead contamination and cadmium in mahogany seeds 0.0607μg/g and<0.003μg/g. The inhibitory diameter of each concentration of seeds against Escherichia coli, 3%, 5%, 7%, and 9%, is 12,67; 13,67; 17,67; and 19,67 mm, respectively. The inhibitory diameter of each concentration of leaves against Escherichia coli, 3%, 5%, 7%, and 9%, is 10,27; 10,90; 13,46; and 15,68 mm, respectively

Item Type:	Article
Uncontrolled Keywords:	Bacteria, Inhibitory test, Mahogany, Puriϑication, Speciϑic parameters, non-speciϑic parameters, Standardization, Swietenia mahagoni (L.) Jacq
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	FAKULTAS FARMASI
Depositing User:	Unnamed user with email admin@umi.ac.id
Date Deposited:	29 May 2023 02:54
Last Modified:	29 May 2023 02:54
URI:	http://repository.umi.ac.id/id/eprint/2556

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