Radiolabeled EGFR Tyrosine Kinase for the Detection of Dual Mutations EGFR L858R/T790M in NSCLC

Fawwaz, Muammar (2023) Radiolabeled EGFR Tyrosine Kinase for the Detection of Dual Mutations EGFR L858R/T790M in NSCLC. Biointerface Research in Applied Chemistry, 13 (5). pp. 1-11. ISSN 2069-5837

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Abstract

Non-small cell lung cancer (NSCLC) is a type of lung cancer that affects 85% of all lung cancer diagnoses. For NSCLC patients, epidermal growth factor receptor – tyrosine kinase inhibitor (EGFR-TKI) is a viable therapeutic approach. However, first- and second-generation EGFR-TKI therapies result in EGFR mutations, eventually leading to resistance. Before administering TKI therapy, the type of mutation in NSCLC must be identified in order to reduce resistance. A biopsy is a common diagnostic technique; however, a repeat biopsy in NSCLC patients is invasive. Due to the small sample size and the heterogeneous nature of cancer, the biopsy was unable to identify the mutation type accurately. The use of molecular imaging techniques such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) is a promising option because it is non-invasive and can determine mutation strata in detail. Thus, this study aims to review the radiotracer developed to detect EGFR mutations, especially the double mutation EGFR L858R/T790M. Literature searches were conducted on reputable databases such as Pubmed, SciFinder, and Scopus. Our results showed that several probes were found that have high in vitro and in vivo selectivity toward double mutations EGFR L858R/T790M, such as [18F]FEWZ, [125I]ICO1686, [77Br]BrCO1686, [125I]I-osimertinib, and [77Br]Br-osimertinib. The summary report explains that these radiotracers are insufficient to produce a high-contrast tumor in tissues. Thus, these radiotracers need to be modified by a structural modification to increase the imaging contrast of the targeted tumor for a clinical study.

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	FAKULTAS FARMASI
Depositing User:	Unnamed user with email admin@umi.ac.id
Date Deposited:	04 Jul 2023 01:37
Last Modified:	04 Jul 2023 01:37
URI:	http://repository.umi.ac.id/id/eprint/2944

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