A Novel ClerodaneDiterpene from Vitex cofassus

Faradiba, Faradiba (2017) A Novel ClerodaneDiterpene from Vitex cofassus. jurnal Chemical and Pharmaceutical Bulletin, 65. pp. 116-120. ISSN 0009-2363

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New clerodane diterpene, 16-hydroxy-pentandralactone (1) and known diterpene acuminolide (2) were isolated from the methanol extract of Vitex cofassus leaves. The chemical structure and the absolute configu�ration of 1 were determined by MS, NMR and electron circular dichroism (ECD) experiments. The isolated compounds were evaluated for their antiproliferative activities against a panel of human tumor cell lines, including a multidrug-resistant (MDR) cell line. Both compounds showed potent antiproliferative activi�ties against all the tested cell lines with IC50 values of 5.4–11.4 µM. Their effects on cell viability were also tested using vascular endothelial growth factor (VEGF)-stimulated human umbilical vein endothelial cells (HUVECs). Compound 1 inhibited VEGF-stimulated HUVEC proliferation in a dose-dependent manner. Based on these results, compound 1 could be a candidate for antitumor agent and inhibitor of angiogenesis. Key words Vitex cofassus; clerodane diterpene; antiproliferative activity; antiangiogenic activity

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Depositing User: Unnamed user with email admin@umi.ac.id
Date Deposited: 14 Oct 2021 02:42
Last Modified: 14 Oct 2021 02:43
URI: http://repository.umi.ac.id/id/eprint/631

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