ANTIINFLAMMATORY EFFECT OF BETA-BETA (Lunasia amara) in WISTAR RATS

Introduction. The Beta-beta (Lunasia amara) extract is being used orally and topically in traditional
Indonesia for the treatment of leg swelling, skin diseases and inflammation or irritation of the eyes. The
anti-inflammatory effect of beta-beta wood were tested in rats induced Complete Freund’s Adjuvant
(CFA) 0,1%.
Aim. Test the effect anti-inflammatory of beta-beta wood (Lunasia amara) in Wistar rats.
Methods. Anti-inflammatory effects of beta-beta was observed at the foot of Wistar rats induced
Complete Freund's Adjuvant (CFA). Animals were divided into 6 groups with each group consisting of 6
animals: the group given extract beta-beta at a dose of 5 mg/kg body weight (BW) and 10 mg/kg BW,
group given a fraction of beta-beta and a control group that controls positive, normal controls and
negative controls. Antiinflammatory effect was observed through a decrease in volume of edema in rats
induced foot CFA. Edema volume measurements using a pletismometer.
Results. Beta-beta wood has anti-inflamamtory effect in Wistar rats induced CFA. The measurement
results between the group given the extract and the fraction of the beta-beta wood compared with
diclofenac sodium control group showed no significant difference (p˂0,05).
Conclusion. Beta-beta wood (Lunasia amara) has anti-inflammatory effects in Wistar rats.
Keyword : Anti-inflammatory, beta-beta (Lunasia amara), Wistar rats, Complete Freund’s adjuvant
(CFA), pletismometer