EFFECT INFLAMMATORY OF LUNASIA AMARA EXTRACT ETHANOLIC ON EXPERIMENTAL CHRONIC ARTHRITIS

The effect of inflammatory of Lunasia amara ethanol extract (LAE) on Freund's complete adjuvant (FCA)-induced arthritis was investigated. Effect inflammatory assessment was done by measuring paw volume (hind paw swelling), joint diameter, and body weight. The oral administration of LAE (50, 100, and 200 mg/kg BW per day) for 60 days after subcutaneous immunization with FCA. The arthritis score and paw edema were markedly suppressed in the groups treated with LAE. The result suggests that the Lunasia amara Extract ethanolic might be beneficial in the treatment of the chronic inflammatory disorder. Keyword: Lunasia amara extract ethanolic, chronic inflammation, FCA-induced arthritis