ANTIINFLAMMATORY EFFECT OF BETA-BETA (Lunasia amara) in WISTAR RATS

Hasnaeni, Hasnaeni (2016) ANTIINFLAMMATORY EFFECT OF BETA-BETA (Lunasia amara) in WISTAR RATS. In: 1ST International conference on Heath Science, UGM.

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Abstract

Introduction. The Beta-beta (Lunasia amara) extract is being used orally and topically in traditional Indonesia for the treatment of leg swelling, skin diseases and inflammation or irritation of the eyes. The anti-inflammatory effect of beta-beta wood were tested in rats induced Complete Freund’s Adjuvant (CFA) 0,1%. Aim. Test the effect anti-inflammatory of beta-beta wood (Lunasia amara) in Wistar rats. Methods. Anti-inflammatory effects of beta-beta was observed at the foot of Wistar rats induced Complete Freund's Adjuvant (CFA). Animals were divided into 6 groups with each group consisting of 6 animals: the group given extract beta-beta at a dose of 5 mg/kg body weight (BW) and 10 mg/kg BW, group given a fraction of beta-beta and a control group that controls positive, normal controls and negative controls. Antiinflammatory effect was observed through a decrease in volume of edema in rats induced foot CFA. Edema volume measurements using a pletismometer. Results. Beta-beta wood has anti-inflamamtory effect in Wistar rats induced CFA. The measurement results between the group given the extract and the fraction of the beta-beta wood compared with diclofenac sodium control group showed no significant difference (p˂0,05). Conclusion. Beta-beta wood (Lunasia amara) has anti-inflammatory effects in Wistar rats. Keyword : Anti-inflammatory, beta-beta (Lunasia amara), Wistar rats, Complete Freund’s adjuvant (CFA), pletismometer

Item Type: Conference or Workshop Item (Paper)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: FAKULTAS FARMASI
Depositing User: Unnamed user with email admin@umi.ac.id
Date Deposited: 16 Feb 2021 03:02
Last Modified: 23 Feb 2021 02:28
URI: http://repository.umi.ac.id/id/eprint/222

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