Cytotoxicity activity oil of Anguilla marmorata (Q.) Gaimard

Jamaluddin, Jamaluddin and Fadriani, Fadriani and Herwin, Herwin (2023) Cytotoxicity activity oil of Anguilla marmorata (Q.) Gaimard. Cytotoxicity activity oil of Anguilla marmorata (Q.) Gaimard, 7 (2). pp. 323-331. ISSN eISSN: 2550-2166

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Abstract

Eel fish (Anguilla marmorata (Q.) Gaimard) contains unsaturated fatty acids such as omega-3 and omega-6. Furthermore, EPA and DHA are forms of omega-3 and are known to treat various diseases such as atherosclerosis, cancer, inflammation, heart disease, stroke, lupus, hypertension, impaired growth and intelligence, diabetes, and act as antifungal agents. This study aimed to determine the cytotoxic activity of eel fish oil extract against Artemia salina leach shrimp larvae using the brine shrimp lethality test (BSLT) method. It also aimed to determine the lethal concentration 50 (LC₅₀) value of the oil, which is the concentration that could cause the death of 50% of the test animal population. The cytotoxicity testing was carried out using the larvae of Artemia salina leach shrimp larvae aged 48 hrs and eel fish oil extract at concentrations of 50, 100, 150, 200, 250, 300, 350, 400, 450, and 500 ppm with five repetitions. Furthermore, the cytotoxic effect was observed by calculating the number of shrimp larvae mortality, while the probit analysis was used to determine the LC50 value of the oil. The results showed that the eel fish oil extract had the highest bioactivity against Artemia salina leach shrimp larvae at concentrations of 200, 250, 300, 350, 400, 450, and 500 ppm, respectively, and its LC₅₀ value was 232.6802 ppm, which is <1000 ppm. Therefore, it was concluded that the oil is toxic to Artemia salina leach shrimp larvae and has the potential to be further investigated as an anticancer agent.

Item Type:	Article
Subjects:	R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	FAKULTAS FARMASI
Depositing User:	operator 8
Date Deposited:	22 Oct 2023 23:41
Last Modified:	22 Oct 2023 23:41
URI:	http://repository.umi.ac.id/id/eprint/4810

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